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1.
Gastroenterol. latinoam ; 31(2): 85-89, 2020. ilus
Article in Spanish | LILACS | ID: biblio-1292373

ABSTRACT

Subepithelial lesions are generally an incidental diagnosis with an prevalence of 0.4%. These tumors represent a great diagnostic challenge, mainly when ruling out potentially malignant lesions, such as gastrointestinal stromal tumor (GIST), lymphomas and carcinomas. Among the many differential diagnosis, the ectopic pancreas arises with an prevalence of 1-2% in general population. The first diagnostic approach is performed using upper digestive endoscopy, computed tomography and endosonography. This last one has a diagnostic performance of less than 50%, which increases to 90% when it is associated with a histopathological examination. There is no current consensus regarding the management and monitoring of these lesions. Based on the imaging and histological characteristics, the possibilities range from observation to endoscopic or surgical resection. In this context, we will present a clinical case of ectopic pancreas as an incidental finding, and afterwards the diagnostic and therapeutic breakdown of subepithelial lesions.


Las lesiones subepiteliales son pesquisadas generalmente de manera incidental, con una prevalencia de 0,4%. Estos tumores suponen un gran desafío diagnóstico, principalmente al momento de descartar lesiones potencialmente malignas, como el tumor estromal gastrointestinal (GIST), linfomas y carcinomas. Dentro de los posibles diagnósticos, surge el páncreas ectópico, con una prevalencia de hasta 1-2% en la población general. La primera aproximación diagnóstica se realiza mediante endoscopia digestiva alta, tomografía computarizada y la endosonografía, ésta última con un rendimiento diagnóstico menor del 50%, que aumenta hasta el 90% al asociar el examen histopatológico. No existe consenso actual respecto al manejo y seguimiento de estas lesiones, que según sus características imagenológicas e histológicas, va desde la observación hasta la resección endoscópica o quirúrgica. En este contexto, se presenta un caso clínico de páncreas ectópico como hallazgo incidental y el desglose diagnóstico y terapéutico de las lesiones subepiteliales.


Subject(s)
Humans , Male , Adult , Pancreas/diagnostic imaging , Choristoma/diagnostic imaging , Stomach Diseases/diagnosis , Endosonography , Gastrointestinal Stromal Tumors/diagnosis , Diagnosis, Differential , Gastrointestinal Neoplasms/diagnosis
2.
Biomédica (Bogotá) ; 39(2): 241-246, ene.-jun. 2019. graf
Article in Spanish | LILACS | ID: biblio-1011436

ABSTRACT

Resumen La anisakiasis es una enfermedad parasitaria zoonótica causada por el consumo de pescados o mariscos crudos o poco cocidos infectados con nematodos de los géneros Anisakis, Pseudoterranova y Contracaecum. Se describe el primer caso de anisakiasis en Colombia y se resume la literatura médica disponible. Una mujer de 52 años de edad consultó por dolor epigástrico agudo de inicio abrupto, náuseas, vómitos, diarrea y urticaria después de consumir pescado. El examen físico reveló sensibilidad moderada en el epigastrio. El examen de laboratorio evidenció leucocitosis, en tanto que la radiografía simple y el electrocardiograma no reflejaron ninguna anormalidad. El diagnóstico se hizo mediante una endoscopia de vías digestivas altas, la cual reveló engrosamiento de la pared gástrica y un parásito en movimiento. Se encontró una larva de Anisakis y se la extrajo por endoscopia, lo que alivió el dolor de la paciente. Clínicamente, la anisakiasis puede presentarse como una enfermedad gástrica, intestinal, en otros sistemas o alérgica. El diagnóstico se hace con base en la elaboración del historial alimentario del paciente y la visualización directa de las larvas; el único tratamiento efectivo consiste en su extracción endoscópica.


Abstract Anisakiasis is a zoonotic parasitic disease caused by consumption of raw or undercooked fish or seafood infected with nematodes of the Anisakis, Pseudoterranova or Contracaecum genera. Here, we describe the first case of anisakiasis in Colombia and summarize the available literature. A 52-year-old female with a history of abrupt-onset sharp epigastric pain, nausea, vomit, diarrhea, and urticaria following fish consumption consulted the health service. The physical examination revealed moderate tenderness of the epigastric region; the laboratory evaluation showed leukocytosis and a simple X-ray and ECG showed no abnormalities. The diagnosis was made by endoscopic examination, which revealed a thickened gastric wall and a moving larval worm. An Anisakis larva was found and extracted endoscopically, which relieved the pain of the patient. Clinically, anisakiasis may present as a gastric, intestinal, extragastrointestinal or allergic disease. Diagnosis and treatment of anisakiasis are made by a dietary history, direct visualization and endoscopic extraction of possible larvae, which is the only effective therapy.


Subject(s)
Animals , Female , Humans , Middle Aged , Stomach Diseases/parasitology , Urticaria/etiology , Food Parasitology , Anisakis/isolation & purification , Anisakiasis/diagnosis , Fishes/parasitology , Raw Foods/adverse effects , Stomach Diseases/diagnosis , Stomach Diseases/immunology , Albendazole/therapeutic use , Gastroscopy , Anisakis/growth & development , Anisakiasis/surgery , Anisakiasis/immunology , Anisakiasis/drug therapy , Colombia , Combined Modality Therapy , Raw Foods/parasitology , Larva , Anthelmintics/therapeutic use
3.
Rev. gastroenterol. Perú ; 39(2): 193-196, abr.-jun. 2019. ilus
Article in Spanish | LILACS | ID: biblio-1058515

ABSTRACT

La mucormicosis es una infección oportunista rara usualmente fatal, que afecta mayoritariamente a personas con déficit inmunológico o patologías asociadas. Hay pocos reportes de esta enfermedad en pacientes sin los factores de riesgo tradicionales, desconociéndose aún cuáles podrían ser las causas predisponentes reales implicadas. Las formas de presentación son rinocerebral, cutánea, pulmonar, gastrointestinal y diseminada. Es por esto que, debido al difícil diagnóstico, alta mortalidad y presentación poco común reportamos el caso de un niño de 4 años sin inmunodeficiencia ni patologías de fondo que desarrolló una mucormicosis esófago-gástrica.


Mucormycosis is a rare, usually fatal, opportunistic infection that mostly affects people with immune deficiency or associated pathologies. There are few reports of this disease in patients without the traditional risk factors, still unknown what could be the real predisposing causes involved. The forms of presentation are rhinocerebral, cutaneous, pulmonary, gastrointestinal and disseminated. This is why, due to the difficult diagnosis, high mortality and uncommon presentation, we report the case of a 4-year-old child without immunodeficiency or background pathologies who developed an esophagogastric mucormycosis.


Subject(s)
Child, Preschool , Humans , Male , Stomach Diseases/microbiology , Mucormycosis , Stomach Diseases/diagnosis , Immunocompetence , Mucormycosis/diagnosis
4.
J. bras. nefrol ; 40(3): 266-272, July-Sept. 2018. tab
Article in English | LILACS | ID: biblio-975906

ABSTRACT

ABSTRACT Introduction: The incidence of gastrointestinal disorders among patients with chronic kidney disease (CKD) is high, despite the lack of a good correlation between endoscopic findings and symptoms. Many services thus perform upper gastrointestinal (UGI) endoscopy on kidney transplant candidates. Objectives: This study aims to describe the alterations seen on the upper endoscopies of 96 kidney-transplant candidates seen from 2014 to 2015. Methods: Ninety-six CKD patients underwent upper endoscopic examination as part of the preparation to receive kidney grafts. The data collected from the patients' medical records were charted on Microsoft Office Excel 2016 and presented descriptively. Mean values, medians, interquartile ranges and 95% confidence intervals of the clinic and epidemiological variables were calculated. Possible associations between endoscopic findings and infection by H. pylori were studied. Results: Males accounted for 54.17% of the 96 patients included in the study. Median age and time on dialysis were 50 years and 50 months, respectively. The most frequent upper endoscopy finding was enanthematous pangastritis (57.30%), followed by erosive esophagitis (30.20%). Gastric intestinal metaplasia and peptic ulcer were found in 8.33% and 7.30% of the patients, respectively. H. pylori tests were positive in 49 patients, and H. pylori infection was correlated only with non-erosive esophagitis (P = 0.046). Conclusion: Abnormal upper endoscopy findings were detected in all studied patients. This study suggested that upper endoscopy is a valid procedure for kidney transplant candidates. However, prospective studies are needed to shed more light on this matter.


RESUMO Introdução: A incidência de doenças gastrointestinais altas em pacientes com doença renal crônica é elevada, porém não há boa correlação entre achados endoscópicos e sintomas. Assim, muitos serviços preconizam a realização de Endoscopia Digestiva Alta (EDA) nos candidatos a transplante renal. Objetivos: Descrever alterações endoscópicas presentes em 96 candidatos a transplante renal no período de 2014 a 2015. Métodos: Noventa e seis pacientes renais crônicos submetidos à EDA como preparo para transplante renal. Prontuários médicos dos pacientes foram revisados, os dados tabulados no programa Microsoft Office Excel 2016 e apresentados de maneira descritiva. Calculou-se média, mediana, intervalo interquartílico e intervalo de confiança de 95% das variáveis utilizadas. Alterações endoscópicas foram apresentadas quanto ao número, intervalo de confiança e valor de P, e correlacionadas com a presença ou ausência de infecção por Helicobacter pylori. Resultados: Dos 96 pacientes, 54,17% eram homens e 45,83% mulheres. As medianas de idade e tempo em diálise foram 50 anos e 50 meses, respectivamente. O achado mais comum na EDA foi pangastrite enantematosa (57,30%), seguida de esofagite erosiva (30,20%). Metaplasia intestinal gástrica e úlcera péptica foram encontradas em 8,33% e 7,30% dos pacientes, respectivamente. Pesquisa para H. pylori foi positiva em 49 pacientes, e somente houve correlação entre infecção por H. pylori e esofagite não erosiva (P = 0,046). Conclusão: Afecções gastrointestinais foram detectadas em todos os pacientes estudados. Os achados deste estudo sugerem que a realização de EDA em candidatos a receber transplante renal é desejável. Entretanto, estudos prospectivos são necessários para responder a esta questão.


Subject(s)
Humans , Male , Female , Adult , Middle Aged , Stomach Diseases/etiology , Duodenal Diseases/etiology , Esophageal Diseases/etiology , Renal Insufficiency, Chronic/complications , Stomach Diseases/diagnosis , Cross-Sectional Studies , Endoscopy, Gastrointestinal , Kidney Transplantation , Duodenal Diseases/diagnosis , Esophageal Diseases/diagnosis , Renal Insufficiency, Chronic/surgery
5.
Rev. méd. Chile ; 146(5): 596-602, mayo 2018. tab, graf
Article in Spanish | LILACS | ID: biblio-961436

ABSTRACT

Background: Helicobacter pylori is the most significant pathogen associated with gastric diseases, including gastric cancer. Infected patients with strains that are CagA-positive generally have worse outcomes than those infected with CagA-negative strains. Patients infected with CagA-positive strains have a higher risk for developing gastric cancer. Aim: To determine the prevalence of CagA-positive H. pylori strains in fecal samples of patients from the Coquimbo Region of Chile, using a non-invasive, nested-qPCR method. Material and Methods: We evaluated 160 patients with gastrointestinal symptoms subjected to an upper gastrointestinal endoscopy. DNA was extracted from fecal samples and tested for the presence of H. pylori using nested-qPCR for the ureC gene, and subsequently compared with the results of histology-Giemsa stain from the patients' endoscopic biopsies. When H. pylori was found, the presence of CagA-positive strains was determined via nested-qPCR. Results: The histology-Giemsa stain was positive for H. pylori infection in 123 patients (76.9%), while the analysis of fecal samples detected H. pylori in 129 patients (80.6%). The sensitivity and specificity of nested-qPCR to detect the bacterium was 96.7 and 73.0% respectively. Among patients with the infection, 25% had CagA-positive strains. Conclusions: In this sample of patients, there is a low prevalence of CagA-positive H. pylori strains.


Subject(s)
Humans , Male , Female , Middle Aged , Stomach Diseases/microbiology , Bacterial Proteins/genetics , DNA, Bacterial/genetics , Helicobacter pylori/genetics , Helicobacter Infections/diagnosis , Feces/microbiology , Antigens, Bacterial/genetics , Stomach Diseases/diagnosis , Bacterial Proteins/isolation & purification , Polymerase Chain Reaction , Endoscopy, Digestive System , Sensitivity and Specificity , Antigens, Bacterial/isolation & purification
6.
Rev. chil. cir ; 70(2): 160-163, 2018. ilus
Article in Spanish | LILACS | ID: biblio-959364

ABSTRACT

Resumen Introducción: Los pólipos gástricos suelen ser hallazgos en la endoscopia digestiva alta. Objetivo: Realizar una revisión de los pólipos gástricos más frecuentes y presentar un caso de manejo de estos con gastrectomía total laparoscópica según el protocolo fast track. Caso clínico: Se presenta el caso de un paciente hombre de 46 años, sin antecedentes mórbidos con poliposis difusa del estómago sintomática, en el que se realiza una gastrectomía total laparoscópica siguiendo el protocolo fast track, siendo dado de alta al cuarto día posoperatorio. Discusión: Los pólipos gástricos más frecuentes son los hiperplásicos, de glándula fúndica, adenomas e inflamatorios. Es fundamental obtener biopsias de estos ya que su histología comandará su manejo y pronóstico. En algunos casos, la gastrectomía total es la indicación debido a su riesgo de malignidad o sintomatología. El protocolo fast track ha demostrado ser una modalidad de manejo posoperatorio que disminuye el tiempo de estadía hospitalaria y presenta una recuperación precoz en comparación con la práctica habitual, sin comprometer la seguridad del paciente.


Introduction: Gastric polyps are commonly found incidentally on upper gastrointestinal endoscopy. Objective: Review the most common gastric polyps and present a case of symptomatic polyps managed with laparoscopic total gastrectomy following the fast track protocol. Clinical case: Patient with symptomatic diffuse gastric polyps who had a total laparoscopic gastrectomy following the fast track protocol, who is discharged at home at fourth day post-surgery. Discussion: The most common are hyperplastic polyps, fundic gland polyps, adenomas and inflammatory fibroid polyps. Is very important to obtain biopsies to assess the histology and malignant potential. In certain cases a total gastrectomy is recommended. The fast track rehabilitation protocol is a safe method to decrease hospital stay and improve recovery.


Subject(s)
Humans , Male , Middle Aged , Polyps/surgery , Stomach Diseases/surgery , Laparoscopy/methods , Gastrectomy/methods , Polyps/diagnosis , Stomach Diseases/diagnosis , Time Factors
7.
Rev. gastroenterol. Perú ; 37(3): 271-274, jul.-sep. 2017. ilus, tab
Article in Spanish | LILACS | ID: biblio-991266

ABSTRACT

Los linfomas son tumores sólidos del sistema linfático y se subdividen en linfomas de Hodgkin y no-Hodgkin. Los tumores no Hodgkin pueden originarse en tejidos no ganglionares como el tubo digestivo y son considerados primarios cuando el compromiso extranodal es igual o superior al 75% con relación al compromiso nodal. Los linfomas extranodales gastrointestinales representan del 1% al 4% de los tumores del tracto digestivo y del 10 al 15% de todos los linfomas no Hodgkin. El estómago es el sitio extranodal más común de los linfomas. Presentamos el caso clínico de un paciente varón sexagenario natural de Chiclayo que se realiza una endoscopía particular por síntomas inespecíficos de dispepsia y sólo se informa gastritis eritematosa y al ser admitido en nuestra institución se le diagnostica por endoscopía, marcadores bioquímicos y anatomopatología como un linfoma gástrico no Hodgkin perforado


Lymphomas are solid tumors of the lymphatic system and these are divided into Hodgkin's and non-Hodgkin lymphoma. Non-Hodgkin tumors may originate from non-nodal tissues such as the gastrointestinal tract and they are considered primary when extranodal involvement is equal to or greater than 75% according to the nodal involvement. Extranodal gastrointestinal lymphomas represent 1% to 4% of tumors of the digestive tract, and 10 to 15% of all non-Hodgkin lymphomas. The stomach is the most common extranodal lymphomas site. We present the clinical case of a sexagenarian male natural of Chiclayo who had an upper GI endoscopy for non-specific symptoms of dyspepsia that only reports gastritis and when admitted to our institution is diagnosed by endoscopy, biochemical markers and pathology as a perforated gastric non-Hodgkin lynphoma


Subject(s)
Aged , Humans , Male , Stomach Neoplasms/diagnosis , Lymphoma, Non-Hodgkin/diagnosis , Spontaneous Perforation/etiology , Stomach Diseases/diagnosis , Stomach Diseases/etiology , Stomach Neoplasms/complications , Lymphoma, Non-Hodgkin/complications , Spontaneous Perforation/diagnosis
8.
Arq. gastroenterol ; 54(1): 11-15, Jan.-Mar. 2017. tab, graf
Article in English | LILACS | ID: biblio-838815

ABSTRACT

ABSTRACT BACKGROUND Gastric subepithelial lesion is a relatively common diagnosis after routine upper endoscopy. The diagnostic workup of an undetermined gastric subepithelial lesion should take into consideration clinical and endoscopic features. OBJECTIVE We aimed to investigate the association between patients' characteristics, endoscopic and echographic features with the histologic diagnosis of the gastric subepithelial lesions. METHODS This is a retrospective study with 55 patients, who were consecutively diagnosed with gastric subepithelial lesions, from October 2008 to August 2011. Patients' characteristics, endoscopic and echografic features of each gastric subepithelial lesion were analysed. Histologic diagnosis provided by EUS-guided fine needle aspiration or endoscopic/surgical resection was used as gold standard. RESULTS The probability of gastrointestinal stromal tumors to be located in the cardia was low (4.5%), while for leiomyoma it was high (>95%). In addition, there was a higher risk of gastrointestinal stromal tumors in patients older than 57 years (OR 8.9; 95% CI), with lesions ≥21 mm (OR 7.15; 95% CI), located at 4th layer (OR 18.8; 95% CI), with positive Doppler sign (OR 9; 95% CI), and irregular outer border (OR 7.75; 95% CI). CONCLUSION The location of gastric subepithelial lesions in the gastric cardia lowers the risk of gastrointestinal stromal tumors. While gastric subepithelial lesions occurring in elderly patients, located in the gastric body, with positive Doppler signal and irregular outer border increase the risk of gastrointestinal stromal tumors.


RESUMO CONTEXTO O diagnóstico das lesões subepiteliais gástricas é relativamente comum após a endoscopia digestiva alta de rotina. A posterior investigação diagnóstica de uma lesão subepitelial gástrica indeterminada deve levar em consideração os aspectos clínicos e endoscópicos. OBJETIVO O objetivo foi avaliar a associação entre as características particulares dos pacientes, endoscópicas e ecográficas dos casos de lesões subepiteliais gástricas com os seus diagnósticos histológicos finais. MÉTODOS Estudo retrospectivo com 55 pacientes, consecutivamente diagnosticados com lesão subepitelial gástrica de outubro de 2008 a agosto de 2011. As características do paciente, endoscópica e ecográfica de cada caso com lesão subepitelial gástrica foram analisadas. O diagnóstico histológico fornecido pela punção aspirativa com agulha fina guiada por ecoendoscopia e/ou a ressecção endoscópica/cirúrgica foram utilizadas como padrão-ouro. RESULTADOS A probabilidade de tumor estromal gastrintestinal ser localizado na cárdia foi baixa (4,5%), enquanto que para o leiomioma foi elevada (>95%). Além disso, houve um maior risco de tumor estromal gastrintestinal em pacientes acima de 57 anos (OR 8,9; IC 95%), com lesão ≥21 mm (OR 7,15; IC 95%), localizada na 4ª camada (OR 18,8; IC 95%), com sinal positivo no Doppler (OR 9; IC 95%), e borda externa irregular (OR 7,75; IC 95%). CONCLUSÃO A localização de uma lesão subepitelial gástrica na cárdia reduz o risco de tumor estromal gastrintestinal. Enquanto que lesões subepiteliais gástricas que ocorrem em pacientes idosos, localizadas no corpo gástrico, com sinal positivo no Doppler e com borda externa irregular aumentam significativamente o risco de tumor estromal gastrintestinal.


Subject(s)
Humans , Male , Female , Adult , Aged , Aged, 80 and over , Young Adult , Stomach Diseases/diagnosis , Stomach Diseases/pathology , Stomach Neoplasms , Predictive Value of Tests , Retrospective Studies , Gastroscopy , Endosonography , Biopsy, Fine-Needle , Middle Aged
9.
An. bras. dermatol ; 91(5): 670-672, Sept.-Oct. 2016. graf
Article in English | LILACS | ID: biblio-827749

ABSTRACT

Abstract: Gastric syphilis is an uncommon extracutaneous manifestation of syphilis, occurring in less than 1% of patients, presenting nonspecific clinical manifestations. In general, it occurs on secondary stage. The critical point is the recognition of the syphilitic gastric involvement, without which there may be incorrect diagnosis of malignancy of the digestive tract. In this report, a case of secondary syphilis with gastric involvement that had complete remission with benzathine penicillin will be described.


Subject(s)
Humans , Male , Middle Aged , Stomach Diseases/diagnosis , Syphilis/diagnosis , Penicillin G Benzathine/therapeutic use , Biopsy , Endoscopy, Gastrointestinal , Anti-Bacterial Agents/therapeutic use
11.
Arq. gastroenterol ; 51(3): 180-185, Jul-Sep/2014. tab
Article in English | LILACS | ID: lil-723852

ABSTRACT

Context Helicobacter pylori (H. pylori) has a worldwide distribution, but the prevalence of infection, virulence factors, and clinical presentation vary widely according to the studied population. In Brazil, a continental country composed of several ethnicities and cultural habits, the behavior of infection also appears to vary, as many other studies have shown. Objectives Describe the prevalence of infection with cagA-positive H. pylori strains in a group of children and adolescents who underwent esophagogastroduodenoscopy in Porto Alegre, Rio Grande do Sul. Methods Fifty-four gastric biopsy specimens of children and adolescents with H. pylori infection demonstrated by histology, urease test and molecular analysis were tested for the presence of cagA positive H. pylori strains by the polymerase chain reaction method. Results he prevalence of cagA-positive H. pylori was 29.6% (95% confidence interval, 18 to 43.6%). There were no statistically significant differences in clinical or demographic characteristics or in the endoscopic and histological features of patients infected with cagA-positive strains as compared with those infected by cagA-negative strains. Conclusions he study showed a low prevalence of infection with cagA-positive H. pylori strains among children and adolescents who underwent EGD in southern Brazil, in comparison to studies conducted with children from other regions of Brazil. There was no association between the presence of cagA-positive strains and more severe clinical presentations in the studied sample. .


Contexto Helicobacter pylori (H. pylori) tem distribuição geográfica universal, embora a prevalência da infecção, os fatores de virulência, bem como a apresentação clínica, variem de acordo com a população estudada. No Brasil, um país continental composto por várias etnias e hábitos culturais diversos, o comportamento da infecção também parece variar, como muitos estudos têm demonstrado. Objetivos Descrever a prevalência da infecção por cepas de H. pylori cagA-positivo em um grupo de crianças e adolescentes submetidos a esofagogastroduodenoscopia em Porto Alegre, Rio Grande do Sul. Métodos Cinquenta e quatro (54) fragmentos de biópsia gástrica com presença de H. pylori demonstrada pela análise histológica, teste da urease e análise molecular foram testados para a presença de cepas de H. pylori cagA-positivo pelo método da reação em cadeia da polimerase. Resultados prevalência de cepas de H. pylori cagA-positivo foi de 29,6% (intervalo de confiança de 95%, 18% a 43,6%). Não houve diferenças estatisticamente significativas nas características clínicas e demográficas e nos achados endoscópicos e histológicos entre os pacientes infectados por cepas de H. pylori cagA-positivo em comparação com os cagA-negativo. Conclusões O estudo demonstrou uma baixa prevalência de infecção por cepas de H. pylori cagA-positivo nas crianças e adolescentes submetidas a esofagogastroduodenoscopia no Sul do Brasil em comparação com os estudos realizados com crianças de outras regiões do Brasil. Não houve associação entre a presença de cepas cagA-positivo e desfechos clínicos desfavoráveis na amostra estudada. .


Subject(s)
Adolescent , Child , Female , Humans , Male , Antigens, Bacterial/isolation & purification , Bacterial Proteins/isolation & purification , Helicobacter Infections/microbiology , Helicobacter pylori/isolation & purification , Stomach Diseases/microbiology , Antigens, Bacterial/genetics , Bacterial Proteins/genetics , Brazil/epidemiology , Cross-Sectional Studies , Endoscopy, Digestive System/methods , Helicobacter Infections/diagnosis , Helicobacter Infections/epidemiology , Helicobacter pylori/genetics , Polymerase Chain Reaction , Prevalence , Stomach Diseases/diagnosis , Stomach Diseases/epidemiology
13.
Arq. gastroenterol ; 51(2): 133-138, Apr-Jun/2014. tab, graf
Article in English | LILACS | ID: lil-713581

ABSTRACT

Context One of the limitations of 13C-urea breath test for Helicobacter pylori infection diagnosis in Brazil is the substrate acquisition in capsule presentation. Objectives The purpose of this study was to evaluate a capsule-based 13C-urea, manipulated by the Pharmacy Division, for the clinical practice. Methods Fifty patients underwent the conventional and the capsule breath test. Samples were collected at the baseline and after 10, 20 and 30 minutes of 13C-urea ingestion. Urease and histology were used as gold standard in 83 patients. Results In a total of 50 patients, 17 were positive with the conventional 13C-urea (75 mg) breath test at 10, 20 and 30 minutes. When these patients repeated breath test with capsule (50 mg), 17 were positive at 20 minutes and 15 at 10 and 30 minutes. The relative sensitivity of 13C-urea with capsule was 100% at 20 minutes and 88.24% at 10 and at 30 minutes. The relative specificity was 100% at all time intervals. Among 83 patients that underwent capsule breath test and endoscopy the capsule breath test presented 100% of sensitivity and specificity. Conclusions Capsule based breath test with 50 mg 13C-urea at twenty minutes was found highly sensitive and specific for the clinical setting. HEADINGS- Helicobacter pylori. Breath Test. Urea, analysis. .


Contexto Uma das limitações para o teste respiratório com 13C-uréia ser incorporado na prática clínica no Brasil para diagnóstico de infecção pelo Helicobacter pylori (H. pylori) é a aquisição do substrato em apresentação de cápsula. Objetivos O objetivo deste estudo foi avaliar a utilidade de 13C-uréia em cápsula, manipulada pela Divisão de Farmácia de um Hospital terciário para a prática clínica. Métodos Cinquenta pacientes foram submetidos ao teste respiratório convencional com 75mg de 13C-uréia e ao teste com cápsula de 50 mg de 13C-uréia. Amostras de ar expirado foram coletadas no basal e após 10, 20 e 30 minutos da ingestão de 13C-uréia para definição do melhor tempo de coleta. A urease e a histologia foram usadas como padrão ouro em 83 pacientes que se submeteram ao teste respiratório com único ponto de coleta. Resultados Num total de 50 pacientes, 17 foram positivos com teste respiratório convencional com 75 mg de 13C-uréia aos 10, 20 e 30 minutos. Quando esses pacientes repetiram o teste respiratório com 13C-uréia em cápsulas de 50 mg, 17 foram positivos aos 20 minutos (Índice Kappa 1,0; P<0,05) e 15 aos 10 e 30 minutos (Índice Kappa 0,90; P<0,05). A sensibilidade relativa da 13C-uréia em cápsulas de 50 mg foi 100% aos 20 minutos e 88,24% aos 10 e 30 minutos. A especificidade relativa foi de 100% em todos os intervalos de tempo. Entre 83 pacientes que se submeteram ao teste respiratório com cápsula e endoscopia, aqueles que eram H. pylori positivos tiveram teste respiratório positivo e aqueles H. pylori negativo tiveram teste respiratório negativo, mostrando sensibilidade e especificidade de 100%. Conclusões O teste respiratório com cápsula de 50 mg de 13C-uréia ...


Subject(s)
Female , Humans , Male , Middle Aged , Breath Tests/methods , Helicobacter pylori , Helicobacter Infections/diagnosis , Stomach Diseases/microbiology , Urea , Urease , Capsules , Endoscopy, Gastrointestinal , Sensitivity and Specificity , Stomach Diseases/diagnosis
16.
Medisur ; 11(1): 80-86, ene.-feb. 2013. graf
Article in Spanish | LILACS | ID: lil-760159

ABSTRACT

Se presenta el caso de una paciente de 40 años con xantelasma gástrico asociado a Helicobacter pylori, asociación infrecuente en la literatura médica. Se resalta la rareza de esta entidad, las manifestaciones clínicas, el diagnóstico, la terapéutica y la importancia de su relación con Helicobacter pylori. Se realizó una revisión de los aspectos más importantes de estos aspectos. Se concluye que el Helicobacter pylori debe tenerse presente por su carácter de agente etiológico en enfermedades malignas y que deben agotarse todos los medios para su oportuna identificación.


The case of a 40 years old patient diagnosed with gastric Xanthelasma related to Helicobacter pylori is presented. This association is rare to find in medical literature. The following aspects are highlighted: entity rareness, clinical manifestations, diagnosis, treatment and importance of the association with Helicobacter pylori. A literature review on the most important features of these processes has been carried out. It has been concluded that Helicobacter pylori should be seriously taken into consideration because of its aetiology in malignant diseases and that all kinds of investigations should be performed in order to diagnose it in due time.


Subject(s)
Humans , Female , Adult , Stomach Diseases/diagnosis , Stomach Diseases/therapy , Helicobacter pylori/pathogenicity
17.
Gastroenterol. latinoam ; 23(2): S87-S90, abr.-jun. 2012. tab
Article in Spanish | LILACS | ID: lil-661624

ABSTRACT

Most of gastric polyps are benign and do not need specific treatment. However, some types have significant malignant potential that can lead to gastric cancer if they are not managed appropriately. The malignant potential depends on the histological type of the polyp, therefore it is important to sample and make biopsies.


La mayoría de los pólipos gástricos son benignos y no requieren tratamiento específico; no obstante, algunos de ellos pueden malignizarse. Si estos pólipos no son tratados pueden ser causa de cáncer gástrico. El potencial maligno depende del tipo histológico del pólipo, por lo que estas lesiones debieran ser siempre biopsiadas.


Subject(s)
Humans , Stomach Diseases/diagnosis , Polyps/diagnosis , Gastric Fundus , Stomach Diseases/pathology , Stomach Diseases/therapy , Hamartoma , Hyperplasia , Polyps/pathology , Polyps/therapy
19.
West Indian med. j ; 60(6): 681-684, Dec. 2011. ilus
Article in English | LILACS | ID: lil-672835

ABSTRACT

We report a case of multiple myeloma associated with light-chain amyloidosis in a 62-year old woman. The patient came to hospital with the main complaint of epigastric pain and gastroscopy showed gastric retention. The patient had been diagnosed with multiple myeloma associated with light-chain amyloidosis after biopsy of the gastric mucosa and bone marrow aspirate. A review of the literature was also performed.


Se reporta el caso de un mieloma múltiple asociado con amiloidosis de cadenas ligeras en una mujer de 62 años de edad. La paciente acudió al hospital aquejada principalmente por un dolor epigástrico y la gastroscopía mostró retención gástrica. A la paciente le había sido diagnosticado un mieloma múltiple asociado con una amiloidosis de cadenas ligeras luego de practicársele una biopsia de la mucosa gástrica y aspirado de la médula ósea. También se realizó una revisión de la literatura.


Subject(s)
Female , Humans , Middle Aged , Amyloidosis/diagnosis , Multiple Myeloma/diagnosis , Stomach Diseases/diagnosis , Diagnosis, Differential
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